INTRODUCTION: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model.
METHODS: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 (n=11, methimazole, MMI -induced hypothyroidism group) given MMIwater, and Group 2 (n=10, control group), normal tap water. When the offspring reached 90 days, they were decapitated and the nasal mucosa was removed. Thyroid hormone receptor (TR-a, TR-b) status was assessed by immunohistochemical staining.
RESULTS: The difference between hypothyroidism and control groups regarding inflammation was statistically significant (p<0.001), as were the differences between hypothyroidism and control groups regarding edema and vascular proliferation (p<0.001, p=0.001). Staining was identified in sebaceous gland structures with immunohistochemical staining for thyroid hormone receptors. No statistically significant difference was found between the hypothyroidism and control groups regarding TR-a and TR-b.
DISCUSSION AND CONCLUSION: Thyroid hormone receptors are present in nasal mucosa. Edema, inflammation, and vascular proliferation occur in nasal mucosa due to hypothyroidism.