E-ISSN 2602-4837
The Turkish Journal of Ear Nose and Throat The effect of experimental hypothyroidism on nasal mucosa [Tr-ENT]
Tr-ENT. 2018; 28(1): 21-25 | DOI: 10.5606/Tr-ENT.2018.91370

The effect of experimental hypothyroidism on nasal mucosa

Yeşim Başal1, Ceren Günel1, Nuket Özkavruk Eliyatkın2, Gökhan Cesur3, Aylin Eryılmaz1
1Department of Otolaryngology, Medical Faculty of Adnan Menderes University, Aydın, Turkey
2Department of Pathology, Medical Faculty of Adnan Menderes University, Aydın, Turkey
3Department of Physiology, Medical Faculty of Adnan Menderes University, Aydın, Turkey

INTRODUCTION: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model.
METHODS: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 (n=11, methimazole, MMI -induced hypothyroidism group) given MMIwater, and Group 2 (n=10, control group), normal tap water. When the offspring reached 90 days, they were decapitated and the nasal mucosa was removed. Thyroid hormone receptor (TR-a, TR-b) status was assessed by immunohistochemical staining.
RESULTS: The difference between hypothyroidism and control groups regarding inflammation was statistically significant (p<0.001), as were the differences between hypothyroidism and control groups regarding edema and vascular proliferation (p<0.001, p=0.001). Staining was identified in sebaceous gland structures with immunohistochemical staining for thyroid hormone receptors. No statistically significant difference was found between the hypothyroidism and control groups regarding TR-a and TR-b.
DISCUSSION AND CONCLUSION: Thyroid hormone receptors are present in nasal mucosa. Edema, inflammation, and vascular proliferation occur in nasal mucosa due to hypothyroidism.

Keywords: hypothyroidism, rhinitis, thyroid hormone receptor, TR-a, TR-b

Yeşim Başal, Ceren Günel, Nuket Özkavruk Eliyatkın, Gökhan Cesur, Aylin Eryılmaz. The effect of experimental hypothyroidism on nasal mucosa. Tr-ENT. 2018; 28(1): 21-25

Corresponding Author: Yeşim Başal, Türkiye
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